Basic infomation |
source |
Mouse |
Clonality |
Polyclonal |
|
Isotype |
IgG |
|
Reactivity |
H M R |
|
MW (kDa) |
112kDa |
|
Purification |
Antigen affinity purfication |
|
UniProt ID |
P12036 |
|
NCBI Gene |
4744 |
|
|
|
|
Applications |
Tested Applications |
WB, |
Cited Applications |
WB, IHC, IF |
|
Product Usage Information |
Western Blotting |
1:1000-1:3000 |
Immunohistochemistry |
1:200-1:400 |
|
Immunofluorescence |
1:200-1:400 |
|
|
|
|
Storage |
PBS with 50% glycerol and less than 0.02% sodium azide |
|
Store at –20°C, stable for one year after shipment |
||
Do not aliquot the antibody |
||
|
||
Background |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. |
|
|
|
|
Abbreviation |
H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken Z: zebrafish Dg: dog Pg: pig Hr: horse |