Basic infomation |
source |
Mouse |
Clonality |
Polyclonal |
|
Isotype |
IgG |
|
Reactivity |
H M R |
|
MW (kDa) |
70kDa |
|
Purification |
Antigen affinity purfication |
|
UniProt ID |
O15350 |
|
NCBI Gene |
7161 |
|
|
|
|
Applications |
Tested Applications |
WB, |
Cited Applications |
WB, IHC, IF |
|
Product Usage Information |
Western Blotting |
1:1000-1:2000 |
Immunohistochemistry |
1:200-1:400 |
|
Immunofluorescence |
1:200-1:400 |
|
|
|
|
Storage |
PBS with 50% glycerol and less than 0.02% sodium azide |
|
Store at –20°C, stable for one year after shipment |
||
Do not aliquot the antibody |
||
|
||
Background |
This gene (TP73) encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. |
|
|
|
|
Abbreviation |
H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken Z: zebrafish Dg: dog Pg: pig Hr: horse |