Basic infomation |
source |
Mouse |
Clonality |
Polyclonal |
|
Isotype |
IgG |
|
Reactivity |
H M R |
|
MW (kDa) |
87kDa |
|
Purification |
Antigen affinity purfication |
|
UniProt ID |
P42224 |
|
NCBI Gene |
6772 |
|
|
|
|
Applications |
Tested Applications |
WB, |
Cited Applications |
WB, IHC, IF |
|
Product Usage Information |
Western Blotting |
1:1000-1:2000 |
Immunohistochemistry |
1:200-1:400 |
|
Immunofluorescence |
1:200-1:400 |
|
|
|
|
Storage |
PBS with 50% glycerol and less than 0.02% sodium azide |
|
Store at –20°C, stable for one year after shipment |
||
Do not aliquot the antibody |
||
|
||
Background |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. |
|
|
|
|
Abbreviation |
H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken Z: zebrafish Dg: dog Pg: pig Hr: horse |