Basic infomation |
source |
Mouse |
Clonality |
Polyclonal |
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Isotype |
IgG |
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Reactivity |
H M R |
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MW (kDa) |
91kDa |
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Purification |
Antigen affinity purfication |
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UniProt ID |
P42229 |
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NCBI Gene |
6776 |
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Applications |
Tested Applications |
WB, |
Cited Applications |
WB, IHC, IF |
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Product Usage Information |
Western Blotting |
1:1000-1:2000 |
Immunohistochemistry |
1:200-1:400 |
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Immunofluorescence |
1:200-1:400 |
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Storage |
PBS with 50% glycerol and less than 0.02% sodium azide |
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Store at –20°C, stable for one year after shipment |
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Do not aliquot the antibody |
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Background |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. |
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Abbreviation |
H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken Z: zebrafish Dg: dog Pg: pig Hr: horse |