Basic infomation |
source |
Mouse |
Clonality |
Polyclonal |
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Isotype |
IgG |
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Reactivity |
H M R |
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MW (kDa) |
75kDa |
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Purification |
Antigen affinity purfication |
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UniProt ID |
P18850 |
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NCBI Gene |
22926 |
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Applications |
Tested Applications |
WB, |
Cited Applications |
WB, IHC, IF |
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Product Usage Information |
Western Blotting |
1:500-1:2000 |
Immunohistochemistry |
1:200-1:400 |
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Immunofluorescence |
1:200-1:400 |
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Storage |
PBS with 50% glycerol and less than 0.02% sodium azide |
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Store at –20°C, stable for one year after shipment |
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Do not aliquot the antibody |
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Background |
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. |
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Abbreviation |
H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken Z: zebrafish Dg: dog Pg: pig Hr: horse |