Basic infomation |
source |
Mouse |
Clonality |
Polyclonal |
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Isotype |
IgG |
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Reactivity |
H M R |
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MW (kDa) |
283kDa |
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Purification |
Antigen affinity purfication |
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UniProt ID |
O00555 |
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NCBI Gene |
773 |
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Applications |
Tested Applications |
WB, |
Cited Applications |
WB, IHC, IF |
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Product Usage Information |
Western Blotting |
1:500-1:2000 |
Immunohistochemistry |
1:200-1:400 |
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Immunofluorescence |
1:200-1:400 |
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Storage |
PBS with 50% glycerol and less than 0.02% sodium azide |
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Store at –20°C, stable for one year after shipment |
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Do not aliquot the antibody |
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Background |
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. |
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Abbreviation |
H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken Z: zebrafish Dg: dog Pg: pig Hr: horse |