Basic infomation

source

Mouse

Clonality

Polyclonal

Isotype

IgG

Reactivity

H M R

MW (kDa)

43kDa

Purification

Antigen affinity purfication

UniProt ID

P50750

NCBI Gene

1025

Applications

Tested Applications

WB,

Cited Applications

WB, IHC, IF

Product Usage

Information

Western Blotting

1:1000-1:2000

Immunohistochemistry

1:200-1:400

Immunofluorescence

1:200-1:400

Storage

PBS with 50% glycerol and less than 0.02% sodium azide

Store at –20°C, stable for one year after shipment

Do not aliquot the antibody

Background

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

Abbreviation

H: human M: mouse R: rat Rb: rabbit Hm: hamster Mk: monkey Vir: virus C: chicken  Z: zebrafish Dg: dog Pg: pig Hr: horse